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&c. used to take their morning-draughts in ale, beer, or wine, which often made them unfit for business. Now they play the good-fellows in this wakeful and civil drink. The worthy gentleman, Sir James Muddiford, who introduced the practice hereof in London, deserves much respect of the whole nation."

It appears, however, that the jealousy with which the use of coffee was viewed, even by the government, arose more from the nature of the conversations that took place in coffeehouses during moments of public excitement, than from the apprehension of any injury that its consumption might have caused to the public health. In the reign of Charles II. coffee-houses were shut up by a proclamation, issued in 1675, as the retailing of coffee "nourished sedition, spread lies, scandalized great men, and might therefore be considered a common nuisance." As a nuisance, its abolition was considered as not being an infringement of the constitution! Notwithstanding this Machiavellian torturing of the letter to serve the spirit, this arbitrary act occasioned loud and violent discontent; and permission was given to reopen coffee-houses, on condition that the landlords should not allow any scandalous papers containing scandalous reports against the government or great men to be read on their premises!

The use, or rather the abuse, of coffee is said to produce feverish heat, anxiety, palpitations, trembling, weakness of sight, and predisposition to apoplexy. Its effects in checking somnolence have been long known. However, the action of this berry differs according to its being roasted or raw. An infusion of torrefied coffee assists digestion, and frequently removes headaches resulting from derangement in the digestive functions. It also neutralizes the effect of narcotics, especially opium, and this power is increased by the addition of lemon juice. A similar mixture has been known to cure obstinate agues. Musgrave and Percival recommended its use in asthma: indeed, most persons who labour under this distressing malady seem to derive relief from its use.

Taking into consideration all that has been advanced in regard to the inconveniences that may attend the use of coffee and tea, they must be considered as overruled by the moral results that have arisen from the introduction of these beverages; and a late writer has observed, that it has "led to the most wonderful change that ever took place in the diet of civilized nations, a change highly important both in a moral and physical point of view. These beverages have the

admirable advantage o affording stimulus without producing intoxication." Raynal observes, that the use of tea has contributed more to the sobriety of the Chinese than the severest laws, the most eloquent discourses, or the best treatises on morality.

The quality and effects of coffee differ according to the manner in which it is roasted. Bernier states that when he was at Cairo there were only two persons in that great city who knew how to prepare it to perfection. If it be underdone, its virtues will not be imparted, and its infusion will load and oppress the stomach; if it be overdone, its properties will be destroyed, and it will heat the body, and act as an astringent.

The best coffee is the Mocha, or that which is commonly called Turkey coffee. It should be chosen of a greenish, light, olive hue; the berries of a middling size, clean, and plump.

The bad effects of coffee may in all likelihood be attributed both to its powerful and stimulating aroma and to its pungent acidity. According to Cadet, this acid is the gallic; while Grindel considers it the kinic, and Pfaff terms it the caffeic acid. When strongly heated, it yields a pyro-caffeic acid, from which may be obtained a most pungent vinegar, that has recently been thrown into trade, but, I believe, with little

or no success.

The principle of coffee is the caffein, discovered by Robiquet, in 1821; and it is to this active principle that its benecial or baneful effects can be attributed. Recent experiments tend to show that it is possessed of powerful febrifuge virtues. To obtain this result, raw coffee has been used. It gives to water a greenish hue, and, thus saturated, it has been called the citrine coffee. Grindel has used this preparation in the treatment of intermittent fevers in the Russian hospital of Dorpat; he also administered the raw coffee in powder. In eighty cases of this fever scarcely any resisted the power of this medicine, given either in decoction, powder, or extract; but he seems to consider the latter form the most effectual. From this physician's observations, coffee may become a valuable addition to our materia medica; and the homœopathic practitioners maintain that they have employed it with great success in various maladies.

374

AQUA TOPHANIA.

It was for a long time supposed that there actually did exist in Italy a secret poison, the effects of which were slow, and even unheeded, until a lingering malady had consumed the sufferer. No suspicions were excited; or, had they led to any post mortem examination, no trace of the terrific preparation's effects could have been detected.

It was towards the year 1659, during the pontificate of Alexander VII., that the existence of this baneful preparation was suspected. Many young women had been left widows; and many younger husbands, who might have ceased to please their wives, had died away. A certain society of young ladies had been observed to meet under the auspices of an elderly matron of rather a questionable character, who had been known in her horoscopic predictions to announce deaths that had but too truly taken place about the period she prophesied. One of the society, it appears, peached against her companions, who were all apprehended and put to the torture; and the lady patroness, whose name was Spara, was executed with four of her pupils. This Spara was a Sicilian, who had obtained the fatal secret from Tofania at Naples. Hence the composition was named aqua Tofania, aqua della Toffana, and acquetta di Napoli. These deadly drops had been charitably distributed by Tofania to various uncomfortable ladies who wished to get rid of their lords, and were contained in small phials, bearing the inscription of "Manna de San Nicolas de Bari." This hag had lived to an old age, but was at length dragged from a monastery, in which she had sought a sanctuary, tortured, and duly strangled, after a confession of her crimes.

Garelli, physician to Charles VI., thus wrote to Hoffmann on the subject: "Your elegant dissertation on the popular errors respecting poisons brought to my recollection a certain slow poison which that infamous poisoner, still alive in prison at Naples, employed to the destruction of upwards of six hundred persons. It was nothing else than crystallized arsenic dissolved in a large quantity of water by decoction, with the addition, but for what purpose I know not, of the herb cymbalaria (antirrhinum). This was communicated to me by his Imperial Majesty himself, and confirmed by the confession of the criminal in the judicial procedure."

Abbé Gagliani, however, gives a different account of the secret Neapolitan drug. "At Naples," he says, "the mixture of opium and cantharides is known to be a slow poison; the surest of all, and the most infallible, as one cannot mistrust it. At first, it is given in small doses, that its effects may be insensible. In Italy it is called aqua di Tufinia: no one can avoid its attacks, since the liquid is as limpid as water, and cannot be suspected. Most of the ladies of Naples have some of it lying carelessly on their toilet-tables with smelling-bottles; but they always can know the fatal phial when they need its contents." A curious observer has remarked on these two preparations, that the mixture of Garelli was, perhaps, intended for husbands, while that of Gagliani was for the use of lovers.

This remark appears judicious, since the potion described by the Abbé was evidently intended as an amorous philter. Under that head I have related many curious circumstances. There is no doubt but that these preparations often contained deadly drugs, the perilous qualities of which were most probably unknown to those who made them up without any sinister motives. Plutarch and Cornelius Nepos inform us that Lucullus, the Roman General, lost his reason, and subsequently his life, from having taken one of these mixtures; and Caius Caligula was driven into a fit of insanity by a philter given to him by his wife Cæsonia, as described by Lucretius:

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Virgil also alludes to the powerful and baneful nature of the plants employed in magical incantations:

Has herbas, atque hæc Ponto mihi lecta venena
Ipse dedit Moris; nascuntur plurima Ponto.
His ego sæpe lupum fieri, et se condere silvis
Morin, sæpe animas imis excire sepulchris,
Atque satas alio vidi traducere messes.

Female poisoners of a somewhat similar description were known amongst the ancients. Nero, when he resolved to destroy Britannicus, sent for one of those murderers, named Locusta, who, convicted of several assassinations, was pardoned, but kept by the emperor to execute his secret purposes. He wished that on this occasion the poison should produce im

mediate death. Locusta prepared a drug that destroyed a goat in a few minutes. This was not sufficiently active. The next preparation killed a hog in a few seconds. It was approved of. The ill-fated youth was seated at the imperial festive board-the potion poured into his goblet--and he died in epileptic convulsions. Nero, undisturbed, requested his guests to remain quiet-the youth he said was subject to similar attacks, which in general were but of short duration; but soon the black, the livid hue of the face betrayed the poison, which the imperial assassin sought to conceal, by ordering this tell-tale sign to be concealed with paint. Sir Henry Halford seems to think that Juvenal alludes to this circumstance in his first Satire.

Instituit rudes melior Locusta propinquas

Per famam et populum nigros effere maritos.

The poisons used by the ancients appear to have been of various kinds; some more slow in their action than others, to suit, most probably, the views of their employers. Socrates, it is supposed, drank the cicuta, the action of which must have been very slow and weak, since his gaoler informed him that if he could exert himself in a warm debate, the effects might be arrested. The philosopher, however, remained tranquil. He shortly after experienced a numbness in the legs, gradually became insensible, and expired in convulsions.

These secret poisons were conveyed in the most stealthy manner. Hence it is related, that the poison prepared by Antipater, to destroy Alexander, had been conveyed in a mule's hoof, being of so corroding a nature, that no metallic vessel could contain it. This absurd story was credited by Plutarch and Quintus Curtius, whereas it appears more probable that poison was carried in an onyx, of which trinkets to contain precious ointments were frequently made, or under a human nail, also called Unguis, or ovvg. The latter case was the opinion of Dr. Heberden.

Sir Henry Halford, in his learned and interesting essay on the deaths of illustrious persons of antiquity, has clearly proved that Alexander was not poisoned, but died of a lingering fever of a remittent type; a disease that was most probably endemic in the marshes surrounding the city of Babylon.

Many absurd ideas regarding venenose substances prevailed in ancient days as well as in modern times. Hannibal

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