TC Publication, Tema 345U.S. Government Printing Office, 1970 |
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Página 25
... organic acid . Thus acylation with D - ( - ) - a - aminophenylacetic acid yields ampicillin , while acylation with 2,6 - dimethoxybenzoic acid and with a - phenoxy- propionic acid yields methicillin and phenethicillin , respectively ...
... organic acid . Thus acylation with D - ( - ) - a - aminophenylacetic acid yields ampicillin , while acylation with 2,6 - dimethoxybenzoic acid and with a - phenoxy- propionic acid yields methicillin and phenethicillin , respectively ...
Página 48
... organic acid addition salts such as the maleate , ace ate , citrate , oxalate , succinate , benzoate , tartrate , fate , 70 malate , mandelate , ascorbate and the like . The e . bon atom of the acyl group ( to which the a - amino gup t ...
... organic acid addition salts such as the maleate , ace ate , citrate , oxalate , succinate , benzoate , tartrate , fate , 70 malate , mandelate , ascorbate and the like . The e . bon atom of the acyl group ( to which the a - amino gup t ...
Página 49
... organic solem sech as ether and the extract is washed with water quickly in the cold , if desired , and then dried , as with ach drous Na , SO , and the carbobenzoxy groups protecting the amino groups are removed by by- drogenation ...
... organic solem sech as ether and the extract is washed with water quickly in the cold , if desired , and then dried , as with ach drous Na , SO , and the carbobenzoxy groups protecting the amino groups are removed by by- drogenation ...
Página 50
... organic solvents which do not contain reactive hydrogen atoma . Examples of such iner solvents are dimethylformamide , dimethylacetamide , chloroforın , ace- tone , methyl isobutyl ketone and diatane . Frequently it is highly ...
... organic solvents which do not contain reactive hydrogen atoma . Examples of such iner solvents are dimethylformamide , dimethylacetamide , chloroforın , ace- tone , methyl isobutyl ketone and diatane . Frequently it is highly ...
Página 51
... organic solvent , for example , butyl acetate , in which the penicillins are soluble . Thus 6 - aminopenicillanic acid was prepared and iso- lated as follows : ( a ) A suria of Penicillium chrysogenum S120C ( ob tained from Professor ...
... organic solvent , for example , butyl acetate , in which the penicillins are soluble . Thus 6 - aminopenicillanic acid was prepared and iso- lated as follows : ( a ) A suria of Penicillium chrysogenum S120C ( ob tained from Professor ...
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6-amino 6-aminopenicillanic acid acetone acylating added addition alleged American Home Products amine ampicillin antibiotic antitrust suit aqueous phase aqueous solution assaying Ayerst barium carbonate Beech-Nut Beecham Group Limited benzylpenicillin Bristol Laboratories Bristol-Myers Company butanol Canada carbonate carboxylic acid catalyst chemical chlorocarbonate cillin Clemm complainants Court Department of Justice E. R. Squibb Example fermentation filed filtered free acid Furazolidone Gram-negative Home Products Corporation hydrochloric acid hydrogen hydrogen at room importer of ampicillin investigation Jersey licensees manufacture method of competition million in 1968 mixture obtained Order be issued patent misuse penicillanic acid penicillin percent pharmaceutical phenylacetic acid plant PREPARATION President reaction respondent room temperature sales of ampicillin section 337 proceeding sell ampicillin semi-synthetic penicillins sodium bicarbonate sodium hydroxide sodium salt solvent Squibb and Sons stirred subsidiary Tariff Commission Temporary Exclusion Order tion triethylamine unfair act unfair method United vacuo Virgin Islands washed with water Wyeth Zenith Laboratories