TC Publication, Tema 345U.S. Government Printing Office, 1970 |
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Página 49
... ether to remove urreacted starting materials . The prod- uct in the aqueous phase is then converted to the free acid , preferably in the old under a layer of ether by the addi- tion of dilute rainoral acid , e.g. , 5 N H2SO , to pH 2 ...
... ether to remove urreacted starting materials . The prod- uct in the aqueous phase is then converted to the free acid , preferably in the old under a layer of ether by the addi- tion of dilute rainoral acid , e.g. , 5 N H2SO , to pH 2 ...
Página 50
... ether , drying the ether and adding at least one equivalent of a solution of potassium 2 - ethyl- bexanoate ( e.g , 0.373 gm./ml . ) in dry n - butanol . The potassium salt forms , precipitates , usually in crystalline form , and is ...
... ether , drying the ether and adding at least one equivalent of a solution of potassium 2 - ethyl- bexanoate ( e.g , 0.373 gm./ml . ) in dry n - butanol . The potassium salt forms , precipitates , usually in crystalline form , and is ...
Página 51
... ether . The extracted aqueous solution is covered with butanol and the pli ad- justed to 2 by the addition of N HCl . The acidified aque ous phase is extracted with butarol , the pH of the aque- ous phase being adjusted to pl 2 each ...
... ether . The extracted aqueous solution is covered with butanol and the pli ad- justed to 2 by the addition of N HCl . The acidified aque ous phase is extracted with butarol , the pH of the aque- ous phase being adjusted to pl 2 each ...
Página 52
... ether . The extracted aqueous solution is covered with butanol and 78 2,085,048 A further 6 g of less pure product is. 9 under similar conditions the half - life ( hours ) of benzyl- penicillin is less than 0.1 . Example 3 PREPARATION OF ...
... ether . The extracted aqueous solution is covered with butanol and 78 2,085,048 A further 6 g of less pure product is. 9 under similar conditions the half - life ( hours ) of benzyl- penicillin is less than 0.1 . Example 3 PREPARATION OF ...
Página 53
... ether and the aqueous layer which separates is removed . The pH is lowered with concentrated hydro- chloric acid to 2 and the penicilin is extracted twice into 300 ml of ether , the ether is washed with water and finally with 75 ml . of ...
... ether and the aqueous layer which separates is removed . The pH is lowered with concentrated hydro- chloric acid to 2 and the penicilin is extracted twice into 300 ml of ether , the ether is washed with water and finally with 75 ml . of ...
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Términos y frases comunes
6-amino 6-aminopenicillanic acid acetone acylating added addition alleged American Home Products amine ampicillin antibiotic antitrust suit aqueous phase aqueous solution assaying Ayerst barium carbonate Beech-Nut Beecham Group Limited benzylpenicillin Bristol Laboratories Bristol-Myers Company butanol Canada carbonate carboxylic acid catalyst chemical chlorocarbonate cillin Clemm complainants Court Department of Justice E. R. Squibb Example fermentation filed filtered free acid Furazolidone Gram-negative Home Products Corporation hydrochloric acid hydrogen hydrogen at room importer of ampicillin investigation Jersey licensees manufacture method of competition million in 1968 mixture obtained Order be issued patent misuse penicillanic acid penicillin percent pharmaceutical phenylacetic acid plant PREPARATION President reaction respondent room temperature sales of ampicillin section 337 proceeding sell ampicillin semi-synthetic penicillins sodium bicarbonate sodium hydroxide sodium salt solvent Squibb and Sons stirred subsidiary Tariff Commission Temporary Exclusion Order tion triethylamine unfair act unfair method United vacuo Virgin Islands washed with water Wyeth Zenith Laboratories