TC Publication, Tema 345U.S. Government Printing Office, 1970 |
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Página 48
... aqueous acid , e.g. , upon oral administration , and of being ineffective against numerous strains of bacteria , e g . , most Gram - negative bacteria . The compounds of the present invention are particularly useful in that they posses ...
... aqueous acid , e.g. , upon oral administration , and of being ineffective against numerous strains of bacteria , e g . , most Gram - negative bacteria . The compounds of the present invention are particularly useful in that they posses ...
Página 49
... aqueous sodium bicarbonate may be used , for example , if necessary to adjust the pH ) with a water - immiscible solvent such as ether to remove urreacted starting materials . The prod- uct in the aqueous phase is then converted to the ...
... aqueous sodium bicarbonate may be used , for example , if necessary to adjust the pH ) with a water - immiscible solvent such as ether to remove urreacted starting materials . The prod- uct in the aqueous phase is then converted to the ...
Página 50
... aqueous media for the reaction , including filtered fermentation broths or aque- ous solutions of crude 6 - aminopenicillarie acid , use can be made of organic solvents which do not contain reactive hydrogen atoma . Examples of such ...
... aqueous media for the reaction , including filtered fermentation broths or aque- ous solutions of crude 6 - aminopenicillarie acid , use can be made of organic solvents which do not contain reactive hydrogen atoma . Examples of such ...
Página 51
... aqueous phase was separated and the pH adjusted to 7.5 . Thres volumes of acetone was then added with stirring to the precipitate removed by centrifuging The dear liquor was then concentrated to 2280 mk and the rll adjusted to 7.0 . It ...
... aqueous phase was separated and the pH adjusted to 7.5 . Thres volumes of acetone was then added with stirring to the precipitate removed by centrifuging The dear liquor was then concentrated to 2280 mk and the rll adjusted to 7.0 . It ...
Página 52
... aqueous sodiurn hydroxide , di solved in dry acetone is surred and cooled to about € 5 --5 C. To this there is added dropwise with continued cooling and stirring a solution of ethyl chlorocarbonate ( 0.1 nole ) . After approximately ten ...
... aqueous sodiurn hydroxide , di solved in dry acetone is surred and cooled to about € 5 --5 C. To this there is added dropwise with continued cooling and stirring a solution of ethyl chlorocarbonate ( 0.1 nole ) . After approximately ten ...
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Términos y frases comunes
6-amino 6-aminopenicillanic acid acetone acylating added addition alleged American Home Products amine ampicillin antibiotic antitrust suit aqueous phase aqueous solution assaying Ayerst barium carbonate Beech-Nut Beecham Group Limited benzylpenicillin Bristol Laboratories Bristol-Myers Company butanol Canada carbonate carboxylic acid catalyst chemical chlorocarbonate cillin Clemm complainants Court Department of Justice E. R. Squibb Example fermentation filed filtered free acid Furazolidone Gram-negative Home Products Corporation hydrochloric acid hydrogen hydrogen at room importer of ampicillin investigation Jersey licensees manufacture method of competition million in 1968 mixture obtained Order be issued patent misuse penicillanic acid penicillin percent pharmaceutical phenylacetic acid plant PREPARATION President reaction respondent room temperature sales of ampicillin section 337 proceeding sell ampicillin semi-synthetic penicillins sodium bicarbonate sodium hydroxide sodium salt solvent Squibb and Sons stirred subsidiary Tariff Commission Temporary Exclusion Order tion triethylamine unfair act unfair method United vacuo Virgin Islands washed with water Wyeth Zenith Laboratories