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THEORETICAL AND EXPERIMENTAL
Structural and Physicochemical Factors in Drug Design
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A/-Mannich bases absorption action activity affinity agents agonist alkylating amine amino acid analogues angiotensin antagonists antibiotics aqueous atoms bacteria binding bioavailability biological blood buspirone carboxyl catalyzed cells chelating chemical cleavage clinical coli complex compounds concentration conformation cyclooxygenase daunomycin delivery derivatives disease dopamine dose effects efficacy enantiomer enzymatic enzyme inhibitors esters example factors Figure formation function GABA GABA-A gastrointestinal gene hormone hydrogen bonds hydrolysis increased inhibition insulin interaction involved ion channels ligand lipid lipophilicity mechanism membrane metabolism metabolites metal ions moiety molecular molecule muscarinic neuronal nitrogen mustard NMDA NSAIDs nucleoside parent drug penicillin peptide pharmacological pharmacophore physiological plasma polypeptide potent prodrug production properties proteins radioligand reaction receptor release ring salicylamides Scheme selective side-effects solubility specific stability steric structure studies substituent substrate subunits synthesis Table target therapeutic therapy timolol tion tissue toxicity treatment uptake vitro vivo water-soluble X-ray